Wired have a good article about Penny Arcade, how they got started, what they do, and all that jazz. A snippet:

But gaming is increasingly a mainstream activity, with titles like Brain Age and the jock-friendly Madden NFL franchise selling more than anything else. A recurring theme of the strip is resentment that the cool kids are encroaching on their turf.

"It's not fair," Krahulik says. "They could be having sex. With women. Why do they want my hobby?"

I love penny arcade and CAD

Saw this on the PA site; I thought it was quite an insightful interview. It helped me understand where Robert Khoo fit into the picture - he seemed to just appear in a strip one day, and was never really explained.

The quote trog gave above was my favourite part of the interview, but it was also quite funny that the interviewer asked Mike's wife about the time he killed her in-strip.